Top Employers in Poplar Bluff & Butler County
| Name | Industry Type | Employees |
| Poplar Bluff Regional Medical Center | Healthcare | 1,127 |
| V.A. Medical Center | Healthcare | 810 |
| Poplar Bluff R-1 Schools | School District | 787 |
| Briggs & Stratton | Manufacturing | 721 |
| FCC Behavioral Health | Healthcare | 584 |
| Mid-Continent Steel and Wire | Manufacturing | 474 |
| Three Rivers College | Education | 442 |
| Walmart | Retail | 419 |
| Gates Corporation | Manufacturing | 400 |
| City of Poplar Bluff | Government | 240 |