Top Employers in Poplar Bluff & Butler County
| Name | Industry Type | Employees |
| Poplar Bluff Regional Medical Center | Healthcare | 1,400 |
| John J. Pershing VA Medical Center | Healthcare | 772 |
| Poplar Bluff R-1 Schools | School District | 754 |
| Briggs & Stratton | Manufacturing | 650 |
| Three Rivers College | Education | 385 |
| Walmart | Retail | 362 |
| Gates Corporation | Manufacturing | 350 |
| City of Poplar Bluff | Government | 225 |
| Mid-Continent Steel & Wire | Manufacturing | 200 |
| FCC Behavioral Health | Healthcare | 185 |